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- Title
Association of the CCL2C polymorphic markers with essential hypertension.
- Authors
Nasibullin, T.; Belongova, V.; Tuktarova, I.; Nikolaeva, I.; Karamova, I.; Mustafina, O.
- Abstract
Chemokine CCL2, or monocytic chemoatractant protein 1 (CCL2/MCP-1) plays an important role in the development of cardiovascular diseases. In the present study, genotypes of four polymorphic markers ( rs1860190, rs1024611, rs3917887, and rs991804) of the CCL2 gene were identified in the population of Tatars (residents of the Republic of Bashkortostan). Analysis of associations of these markers with essential hypertension (EH) was carried out. It was demonstrated that haplotype CCL2*A*G*D*T was associated with the increased risk of EH ( P = 0.01; OR = 1.53).
- Subjects
CHEMOKINES; GENETIC markers; GENETIC polymorphisms; ESSENTIAL hypertension; CARDIOVASCULAR diseases; TATARS; POPULATION genetics
- Publication
Russian Journal of Genetics, 2011, Vol 47, Issue 9, p1124
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795411090134