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- Title
Citrullus colocynthis -Mediated Green Synthesis of Silver Nanoparticles and Their Antiproliferative Action against Breast Cancer Cells and Bactericidal Roles against Human Pathogens.
- Authors
Rasool, Shafqat; Tayyeb, Asima; Raza, Muhammad Akram; Ashfaq, Hanfa; Perveen, Sadia; Kanwal, Zakia; Riaz, Saira; Naseem, Shahzad; Abbas, Nadeem; Ahmad, Naushad; Alomar, Suliman Yousef
- Abstract
The present study investigated the biomedical potential of eco-friendly Citrullus colocynthis-mediated silver nanoparticles (Cc-AgNPs). The antibacterial efficacy of Cc-AgNPs was evaluated against two multidrug-resistant pathogenic bacterial strains, Escherichia coli and Pseudomonas aeruginosa. The antiproliferative and antilipidemic performance of the prepared particles was determined against the MCF7 cell line, a breast cancer cell line. The in vitro antibacterial assay revealed that Cc-AgNPs induced dose-dependent bactericidal activity, as a considerable increase in the zone of inhibition (ZOI) was noted at higher concentrations. Reduced proliferation, migration, spheroid size, and colony formation exhibited the substantial antiproliferative potential of Cc-AgNPs against MCF7 cells. Significant alterations in the expression of cell surface markers, apoptosis, and cell proliferation genes further confirmed the antiproliferative impact of Cc-AgNPs. Moreover, Cc-AgNPs exhibited antilipidemic activity by reducing cellular cholesterol and triglyceride levels and regulating key genes involved in lipogenesis. In conclusion, these results propose that Cc-AgNPs can be employed as a potent tool for future antibacterial and anticancer applications
- Subjects
WATERMELONS; SILVER nanoparticles; BREAST cancer; CELL lines; CELL proliferation; CANCER cells
- Publication
Nanomaterials (2079-4991), 2022, Vol 12, Issue 21, p3781
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano12213781