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- Title
Impact of ovarian stimulation on mid-luteal endometrial tissue and secretion markers of receptivity.
- Authors
van der Gaast, M. H.; Classen-Linke, I.; Krusche, C. A.; Beier-Hellwig, K.; Fauser, B. C. J. M.; Beier, H. M.; Macklon, N. S.
- Abstract
The objective of this study was to investigate the effect of ovarian stimulation for IVF on endometrial secretion and tissue markers of receptivity in the mid-luteal phase. In 10 oocyte donors, endometrial secretions and biopsies were sampled 5 days after spontaneous ovulation and oocyte retrieval in consecutive cycles. Four subjects received progesterone in the luteal phase of the stimulated cycles. Mid-luteal endometrial maturation in the stimulated cycle was compared with the spontaneous cycle, by histological dating, Ki-67, oestrogen receptor (ER) and progesterone receptor (PR) expression, secretion levels of leukaemia inhibitory factor (LIF), glycodelin A (GdA) and progesterone, and protein profile. No significant differences in histological markers, expression of Ki-67. PR, ER, secretion protein profiles or concentrations of LIE GdA, or progesterone were observed when comparing natural with stimulated cycles. Progesterone supplementation of stimulated cycles was associated with significantly lower Ki-67 (P = 0.03) and ER (P = 0.04) expression compared with the non-supplemented stimulated cycle. In this pilot study, ovarian stimulation was not demonstrated to alter the studied markers of endometrial maturation in the mid-luteal phase.
- Subjects
OVARIES; LUTEAL phase; ENDOMETRIUM; TISSUES; OVULATION; OVUM; ESTROGEN receptors; PROGESTERONE receptors
- Publication
Reproductive BioMedicine Online (Reproductive Healthcare Limited), 2008, Vol 17, Issue 4, p553
- ISSN
1472-6483
- Publication type
Article
- DOI
10.1016/S1472-6483(10)60244-1