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- Title
Two faces of competition: target-mediated reverse signalling in microRNA and mitogen-activated protein kinase regulatory networks.
- Authors
Yongjin Jang; Kim, Min A.; Yoosik Kim
- Abstract
Biomolecular regulatory networks are organised around hubs, which can interact with a large number of targets. These targets compete with each other for access to their common hubs, but whether the effect of this competition would be significant in magnitude and in function is not clear. In this review, the authors discuss recent in vivo studies that analysed the system level retroactive effects induced by target competition in microRNA and mitogen-activated protein kinase regulatory networks. The results of these studies suggest that downstream targets can regulate the overall state of their upstream regulators, and thus cannot be ignored in analysing biomolecular networks.
- Subjects
BIOMOLECULE analysis; BIOMOLECULES; MITOGEN-activated protein kinases; MICRORNA; PROTEIN kinases
- Publication
IET Systems Biology (Wiley-Blackwell), 2017, Vol 11, Issue 4, p105
- ISSN
1751-8849
- Publication type
Article
- DOI
10.1049/iet-syb.2016.0042