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- Title
Mortality in mothers after perinatal loss: a population-based follow-up study.
- Authors
Hvidtjørn, D; Wu, C; Schendel, D; Thorlund Parner, E; Brink Henriksen, T
- Abstract
<bold>Objective: </bold>To assess whether mothers who lost a child from stillbirth or in the first week of life have an increased overall mortality and cause-specific mortality.<bold>Design: </bold>A population based follow-up study.<bold>Setting: </bold>Data from Danish national registers.<bold>Population: </bold>All mothers in Denmark were included in the cohort at time of their first delivery from 1 January 1980 to 31 December 2008 and followed until 31 December 2009 or death, whichever came first.<bold>Methods: </bold>The association between perinatal loss and total and cause-specific mortality in mothers was estimated with hazard ratios (HR) and 95% confidence intervals (95% CI) calculated using Cox proportional hazards regression analyses.<bold>Main Outcome Measures: </bold>Overall mortality and cause-specific mortality.<bold>Results: </bold>During the follow-up period, 838,331 mothers in the cohort gave birth to one or more children and 7690 mothers (0.92%) experienced a perinatal loss. During follow-up, 8883 mothers (1.06%) died. There was an increased overall mortality for mothers who experienced a perinatal loss adjusted for maternal age and educational level, hazard ratio (HR) 1.83 [95% confidence interval (CI) 1.55-2.17]. The strongest association was seen in mortality from cardiovascular diseases (CVD) with an HR of 2.29 (95% CI 1.48-3.52) adjusted for CVD at time of delivery. We found no association between a perinatal loss and mortality from traumatic causes.<bold>Conclusions: </bold>Mothers who experience a perinatal loss have an increased mortality, especially from CVD.
- Subjects
PERINATAL death; MATERNAL mortality; STILLBIRTH; FOLLOW-up studies (Medicine); CARDIOVASCULAR disease related mortality; CAUSES of death; LONGITUDINAL method; QUESTIONNAIRES
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2016, Vol 123, Issue 3, p393
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/1471-0528.13268