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- Title
Human CD8<sup>+</sup> T-cell differentiation in response to viruses.
- Authors
Van Lier, René A. W.; Ten Berge, Ineke J. M.; Gamadia, Laila E.
- Abstract
CD8+ T cells are essential in the defence against viruses. Recently, peptide-HLA class I tetramers have been used to study immune responses to viruses in humans. This approach has indicated consecutive stages of human CD8+ T-cell development in acute viral infection and has illustrated the heterogeneity of CD8+ T cells that are specific for latent viruses. Here, we summarize these findings and discuss their significance for our understanding of antigen-induced CD8+ T-cell maturation in humans.
- Subjects
T cells; VIRUSES; IMMUNOLOGY; PEPTIDES; IMMUNE response; VIRUS diseases
- Publication
Nature Reviews Immunology, 2003, Vol 3, Issue 12, p931
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri1254