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- Title
The role of genomic imprinting in biology and disease: an expanding view.
- Authors
Peters, Jo
- Abstract
Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene expression according to parental origin. It has long been established that imprinted genes have major effects on development and placental biology before birth. More recently, it has become evident that imprinted genes also have important roles after birth. In this Review, I bring together studies of the effects of imprinted genes from the prenatal period onwards. Recent work on postnatal stages shows that imprinted genes influence an extraordinarily wide-ranging array of biological processes, the effects of which extend into adulthood, and play important parts in common diseases that range from obesity to psychiatric disorders.
- Subjects
BIOLOGICAL libraries; GENOMIC imprinting; ETIOLOGY of diseases; MEDICAL sciences; GENE expression
- Publication
Nature Reviews Genetics, 2014, Vol 15, Issue 8, p517
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg3766