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- Title
Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice.
- Authors
Pérez, Viviana I.; Cortez, Lisa A.; Lew, Christie M.; Rodriguez, Marisela; Webb, Celeste R.; Van Remmen, Holly; Chaudhuri, Asish; Qi, Wenbo; Lee, Shuko; Bokov, Alex; Fok, Wilson; Jones, Dean; Richardson, Arlan; Yodoi, Junji; Zhang, Yiqiang; Tominaga, Kaoru; Hubbard, Gene B.; Ikeno, Yuji
- Abstract
We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1)+/0]. The Tg(TRX1)+/0 mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1)+/0 mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1)+/0 mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1)+/0 mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1)+/0 mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.
- Subjects
LIFE spans; AGING; LABORATORY mice; THIOREDOXIN
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2011, Vol 66A, Issue 12, p1286
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glr125