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- Title
Bone mineral density in ambulatory patients with multiple sclerosis.
- Authors
Sioka, Chrissa; Papakonstantinou, Stylianos; Fotopoulos, Andreas; Alamanos, Yiannis; Georgiou, Athanasia; Tsouli, Sofia; Pelidou, Sygliti-Henrietta; Kyritsis, Athanassios; Kalef-Ezra, John
- Abstract
Multiple sclerosis (MS) may be associated with reduced bone mass and higher frequency of osteoporosis. Femoral and spinal bone mineral density (BMD) in 70 ambulatory MS patients (46 females and 24 males) was compared with 100 sex-, age-, and BMI-matched control individuals. BMD was reduced in male patients (lumbar spine 0.976 ± 0.114 g/cm compared with 1.059 ± 0.147 g/cm in controls, p = 0.024, total hip 0.946 ± 0.136 g/cm compared to 1.036 ± 0.118 g/cm in controls, p = 0.008, femoral neck 0.812 ± 0.136 g/cm compared with 0.887 ± 0.135 g/cm in controls p = 0.042), and only in the total hip in female patients (0.88 ± 0.127 g/cm compared with 0.935 ± 0.112 g/cm in controls, p = 0.018). Multivariate analysis demonstrated that the predominantly affected site was the hip. MS patients exhibit increased frequency of low bone mass compared with controls. Further studies should assess the etiologic factors and employ appropriate therapies.
- Subjects
BONE density; MULTIPLE sclerosis; OSTEOPOROSIS; OSTEOPENIA; FEMUR neck; MULTIVARIATE analysis; ETIOLOGY of diseases; OUTPATIENT medical care; PATIENTS
- Publication
Neurological Sciences, 2011, Vol 32, Issue 5, p819
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-011-0623-3