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- Title
The development of primitive tumour and ganglionary invasion in mammary cancer.
- Authors
Morocoasa, C.; Cizevschi, C.; Ichim, M. K.
- Abstract
The local development of the tumour is achieved by direct invasion of the breast parenchyma, gradually extending to the surface and catching the skin, followed by tegument retraction, cutaneous edema and ultimately ulceration. The in-depth evolution of the local extension will affect the large pectoral fascia, then the pectoral muscle, and finally the ribs and the intercostal muscles, even invading the thoracic organs. The local invasion is done both by canalicular path and via lymphatic vessels. These multiple mechanisms of intra-mammary dissemination largely explain the extension of the disease away from the macroscopic margins of the tumour, known as multifocality, which require differentiation from multicentricity (the presence of different outbreaks of disease in different quadrants without causation between them). Studies show that breast cancer is often multifocal and rarely multicentre. The presence of residual microscopic lesions after conservative surgical treatment is the cause of local relapse, occurring most often near the postoperative scar.
- Subjects
MAMMARY gland tumors; BIOLOGICAL invasions; EDEMA
- Publication
Oncolog-Hematolog, 2017, Issue 39, p66
- ISSN
2066-8716
- Publication type
Abstract