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- Title
Genetic Regulation of Life Span, Metabolism, and Body Weight in Pohn, a New Wild-Derived Mouse Strain.
- Authors
Yuan, Rong; Flurkey, Kevin; Meng, Qingying; Astle, Mike C.; Harrison, David E.
- Abstract
Quantitative trait loci (QTL) of longevity identified in human and mouse are significantly colocalized, suggesting that common mechanisms are involved. However, the limited number of strains that have been used in mouse longevity studies undermines the ability to identify longevity genes. We crossed C57BL/6J mice with a new wild-derived strain, Pohn, and identified two life span QTL—Ls1 and Ls2. Interestingly, homologous human longevity QTL colocalize with Ls1. We also defined new QTL for metabolic heat production and body weight. Both phenotypes are significantly correlated with life span. We found that large clone ratio, an in vitro indicator for cellular senescence, is not correlated with life span, suggesting that cell senescence and intrinsic aging are not always associated. Overall, by using Pohn mice, we identified new QTL for longevity-related traits, thus facilitating the exploration of the genetic regulation of aging.
- Subjects
GENETICS of aging; LABORATORY mice; GENETICS of longevity; LIFE spans; PHYSIOLOGY; GENETICS
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2013, Vol 68, Issue 1, p27
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/gls104