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- Title
Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count≥300 cells/μL who were assigned to 7.5 MIU interleukin-2.
- Authors
Fox, Zoe
- Abstract
Background ESPRIT is a randomized trial comparing the clinical impact of interleukin (IL)-2 plus antiretrovirals vs antiretrovirals alone. Identification of factors that influence the relationship between IL-2 and CD4 count recovery will enable better personalization of treatment with IL-2 in HIV-1-positive individuals. The IL-2 induction phase consists of three dosing cycles over 6–8 months (7.5 MIU twice a day, for 5 days every 8 weeks). Methods We included patients initiating IL-2 at the 7.5 MIU dose with an 8-month CD4 count, measured at least 30 days after their last cycle. We identified baseline predictors of CD4 count changes over 8 months using linear regression. Results Of 2090 patients assigned IL-2, 1673 (80%) were included in the analysis. The median (interquartile range) baseline CD4 count was 461 (370, 587) cells/μL with a median increase of 233 (90, 411) cells/μL at month 8. After adjustments, significant predictors of CD4 count change included CD4 nadir (29.8 cells/μL greater increase per 100 cells/μL higher; P<0.0001), last CD4 count before baseline (mean 36.0 cells/μL greater increase per 100 cells/μL higher; P<0.0001), time from antiretroviral start to baseline (8.3 cells/μL smaller increase per year longer; P=0.001), age (11.7 cells/μL smaller increase per 5 years older; P=0.005) and race (79.7 cells/μL greater increase for black patients vs white patients; P=0.003). A linear relationship existed between total IL-2 dose in the first cycle and CD4 count change (73.1 cells/μL greater increase per 15 MIU higher; P<0.0001). Conclusions Prior nadir and current CD4 counts, age and IL-2 dose are major determinants of CD4 increases induced by with intermittent administration of IL-2 in HIV-1-positive individuals on antiretrovirals. The clinical function of these induced CD4 cells is under study.
- Subjects
HIV-positive persons; CD4 antigen; VIRAL receptors; HIV infections; ANTIVIRAL agents; DRUG administration
- Publication
HIV Medicine, 2007, Vol 8, Issue 2, p112
- ISSN
1464-2662
- Publication type
Article
- DOI
10.1111/j.1468-1293.2007.00440.x