We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice.
- Authors
Agarwal, Nidhi Bharal; Jain, Seema; Nagpal, Dheeraj; Agarwal, Nitin Kumar; Mediratta, Pramod K.; Sharma, Krishna K.
- Abstract
Contemporary research indicates promising anticonvulsant effect of curcumin. However, its poor oral bioavailability is a major hindrance toward its pharmacological action. Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice. Liposome-entrapped curcumin in doses 25 and 50 mg/kg demonstrated significant increase in seizure threshold current and latency to myoclonic and generalized seizures in ICES test and PTZ-induced seizures, respectively. Similarly, liposomal-entrapped curcumin also increased the latency to the onset and decreased the duration of seizures during status epilepticus in mice. To conclude, liposomal-entrapped curcumin possesses anticonvulsant activity against status epilepticus in mice.
- Subjects
CURCUMIN; EPILEPSY in animals; LABORATORY mice; BIOAVAILABILITY; SPASMS; ELECTROCONVULSIVE therapy; PATIENTS
- Publication
Fundamental & Clinical Pharmacology, 2013, Vol 27, Issue 2, p169
- ISSN
0767-3981
- Publication type
Article
- DOI
10.1111/j.1472-8206.2011.01002.x