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- Title
Gelatinase expression at positive patch test reactions.
- Authors
Giannelli, Gianluigi; Foti, Caterina; Marinosci, Felice; Bonamonte, Domenico; Antonaci, Salvatore; Angelini, Giovanni
- Abstract
Matrix metalloproteases (MMPs) are proteolytic enzymes involved in tissue remodelling and extracellular matrix (ECM) turnover. They are secreted in a latent form and activated at the cellular surface by a membrane type-1 MMP (MT1-MMP) and a tissue inhibitor of MMP-2 (TIMP-2) that is also responsible for striking a balance between the proteolytic enzymes and TIMP-2. In allergic contact dermatitis (ACD) patients, MMP-2 and MMP-9, two members of the MMPs family, were increased during the challenge phase, in involved but not uninvolved skin. In contrast, TIMP-2 was more evident in uninvolved than involved skin, while no differences were observed with regard to MT1-MMP staining. Comparing the serum of ACD patients with that of healthy subjects, these differences were not observed. These data suggest that MMP-2 and MMP-9 could play a role in the mechanisms inducing alterations of the epidermal architecture, and in the pathogenesis of the lesions.
- Subjects
METALLOPROTEINASES; EXTRACELLULAR matrix; CONTACT dermatitis
- Publication
Contact Dermatitis (01051873), 2002, Vol 46, Issue 5, p280
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1034/j.1600-0536.2002.460506.x