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- Title
Antioxidative potential of alpha-mangostin against hydrogen peroxide induced oxidative stress in human sperm.
- Authors
Wanlapa Kokmas; Onrawee Khongsombat; Hathairat Kruevaisayawan; Waree Tiyaboonchai; Patcharada Amatyakul
- Abstract
Oxidative stress has detrimental effects on sperm viability and fertility, and antioxidant supplementation can improve sperm quality and function. Alpha-mangostin (α-MG) has high potential antioxidants, but its effects on human sperm quality have not been thoroughly explored. This study aimed to investigate the effects of α-MG on sperm motility, acrosome reaction after ionophore challenge (ARIC), enzymatic antioxidative activities, and malondialdehyde (MDA) levels in human sperm. Semen samples from 30 men were subjected to 150 µM of H2O2 (to induce oxidative stress) and various combinations of α-MG (25 µM and 50 µM). The results indicated that supplementing sperm with α-MG at 25 µMand 50 µMsignificantly increased the percentage of progressive sperm motility. Both α-MG concentrations resulted in significant reduction in the ARIC index. MDA levels in samples supplemented with α-MG were lower than in samples without α-MG. The concentration of α-MG at 50 µM substantially improved the catalase activity, and at 25 µM, substantially enhanced the glutathione peroxidase (GPx) activity. In summary, supplementation of α-MG optimized the motility and acrosome reaction index of human sperm exposed to oxidative stress.
- Subjects
OXIDATIVE stress; HYDROGEN peroxide; SPERMATOZOA; ACROSOME reaction; GLUTATHIONE peroxidase
- Publication
ScienceAsia, 2022, Vol 48, Issue 5, p552
- ISSN
1513-1874
- Publication type
Article
- DOI
10.2306/scienceasia1513-1874.2022.083