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- Title
FAPI PET/CT Imaging—An Updated Review.
- Authors
Chandekar, Kunal Ramesh; Prashanth, Arun; Vinjamuri, Sobhan; Kumar, Rakesh
- Abstract
Despite revolutionizing the field of oncological imaging, Positron Emission Tomography (PET) with [18F]Fluorodeoxyglucose (FDG) as its workhorse is limited by a lack of specificity and low sensitivity in certain tumor subtypes. Fibroblast activation protein (FAP), a type II transmembrane glycoprotein, is expressed by cancer-associated fibroblasts (CAFs) that form a major component of the tumor stroma. FAP holds the promise to be a pan-cancer target, owing to its selective over-expression in a vast majority of neoplasms, particularly epithelial cancers. Several radiolabeled FAP inhibitors (FAPI) have been developed for molecular imaging and potential theranostic applications. Preliminary data on FAPI PET/CT remains encouraging, with extensive multi-disciplinary clinical research currently underway. This review summarizes the existing literature on FAPI PET/CT imaging with an emphasis on diagnostic applications, comparison with FDG, pitfalls, and future directions.
- Subjects
COMPUTED tomography; POSITRON emission tomography; DIAGNOSTIC imaging
- Publication
Diagnostics (2075-4418), 2023, Vol 13, Issue 12, p2018
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics13122018