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- Title
Short-Term CPAP Improves Biventricular Function in Patients with Moderate-Severe OSA and Cardiometabolic Comorbidities.
- Authors
Zota, Ioana Mădălina; Sascău, Radu Andy; Stătescu, Cristian; Tinică, Grigore; Leon Constantin, Maria Magdalena; Roca, Mihai; Boișteanu, Daniela; Anghel, Larisa; Mitu, Ovidiu; Mitu, Florin; Balserak, Bilgay Izci
- Abstract
Obstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing, exhibiting an increasing prevalence and several cardiovascular complications. Continuous positive airway pressure (CPAP) is the gold-standard treatment for moderate-severe OSA, but it is associated with poor patient adherence. We performed a prospective study that included 57 patients with newly diagnosed moderate-severe OSA, prior to CPAP initiation. The objective of our study was to assess the impact of short-term CPAP on ventricular function in patients with moderate-severe OSA and cardiometabolic comorbidities. The patients underwent a clinical exam, ambulatory blood pressure monitoring and comprehensive echocardiographic assessment at baseline and after 8 weeks of CPAP. Hypertension, obesity and diabetes were highly prevalent among patients with moderate-severe OSA. Baseline echocardiographic parameters did not significantly differ between patients with moderate and severe OSA. Short-term CPAP improved left ventricular global longitudinal strain (LV-GLS), isovolumetric relaxation time, transmitral E wave amplitude, transmitral E/A ratio, right ventricular (RV) diameter, RV wall thickness, RV systolic excursion velocity (RV S') and tricuspid annular plane systolic excursion (TAPSE). Short-term CPAP improves biventricular function, especially the LV-GLS, which is a more sensitive marker of CPAP-induced changes in LV systolic function, compared to LVEF. All these benefits are dependent on CPAP adherence.
- Subjects
AMBULATORY blood pressure monitoring; CONTINUOUS positive airway pressure; CARDIAC pacing; PATIENT compliance; SLEEP apnea syndromes; CARDIOLOGICAL manifestations of general diseases
- Publication
Diagnostics (2075-4418), 2021, Vol 11, Issue 5, p889
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics11050889