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- Title
Reciprocal relationship of Tn/ NF-κ B and s Tn as an indicator of the prognosis of oral squamous cell carcinoma.
- Authors
Lin, Chi‐Yu; Ho, Jar‐Yi; Hsieh, Meng‐Ti; Chiang, Hsiao‐Ling; Chuang, Jei‐Min; Whang‐Peng, Jacqueline; Chang, Yun‐Ching; Tseng, Yi‐Han; Chen, Su‐Feng; Nieh, Shin; Hwang, Jaulang
- Abstract
Aims In order to determine whether the expression of tumour-associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor-κB (NF-κB), is associated with the invasiveness of oral squamous cell carcinoma ( OSCC), this study has attempted to investigate the correlation of the aforementioned markers with the well-established invasive pattern grading score (IPGS) and clinicopathological parameters. Methods and results Specimens from 143 OSCC patients with classified clinicopathological parameters and IPGS were stained immunohistochemically using anti-Tn, sTn and NF-κB antibodies. Our results showed that the expression of both Tn and NF-κB was correlated positively with staging ( P = 0.036; P = 0.015), recurrence ( P < 0.001; P < 0.001) and distant metastasis ( P = 0.005; P = 0.009), as well as with IPGS, while the expression of sTn was correlated inversely. In addition, poor survival was associated with overexpression of Tn and NF-κB but not with expression of sTn. Conclusions Our results indicate that a reciprocal relationship between Tn and sTn expression may serve as a reliable indicator for OSCC prognostic evaluation. In addition, expression of Tn rather than sTn may play an important role in deeply invasive OSCC via regulation of NF-κB signalling.
- Subjects
SQUAMOUS cell carcinoma; CARCINOMA; TUMORS; ANTIGENS; CANCER invasiveness; IMMUNOHISTOCHEMISTRY
- Publication
Histopathology, 2014, Vol 64, Issue 5, p713
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.12309