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- Title
Loss-of-function mutations are main drivers of adaptations during short-term evolution.
- Authors
Klim, Joanna; Zielenkiewicz, Urszula; Kaczanowski, Szymon
- Abstract
We noticed that during short-term experimental evolution and carcinogenesis, mutations causing gene inactivation (i.e., nonsense mutations or frameshifts) are frequent. Our meta-analysis of 65 experiments using modified dN/dS statistics indicated that nonsense mutations are adaptive in different experimental conditions and we empirically confirmed this prediction. Using yeast S. cerevisiae as a model we show that fixed or highly frequent gene loss-of-function mutations are almost exclusively adaptive in the majority of experiments.
- Subjects
NONSENSE mutation; GENE silencing; GENETIC mutation
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-57694-8