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- Title
Requirement of H--2-subregion differences for graft--versus--host autoimmunity in mice: superiority of the differences at Class--II H--2 antigens (I--A/I--E).
- Authors
Kimura, Mikio; van Rappa Rd-van der Veen, Feikje M.; Gleich- Mann, E.
- Abstract
The effect of various H-2-subregion differences on graft-versus-host (GVH) autoimmunity in mice was investigated by testing a variety of GVH combinations in which non-irradiated adult F1 hybrid mice were injected with parental strain lymphoid cells. As with previous results, the superiority of Class-II H-2 antigen (I-A/I-E) differences to other kinds of H-2 incompatibilities, such as Class-I H-2 antigen (H-2K/H-2D) differences, was largely confirmed. Anti-nuclear antibodies were produced significantly across Class-I as well as Class-II H-2 differences. However, the productions of anti-erythrocyte and anti-thymocyte autoantibodies were mainly confined to GVH reactions induced across Class-II H-2 antigens. Elevated proteinuria was elicited only in the GVH combination that included the differences at Class-II H-2 antigens. GVH autoimmunity, however, did not always result in the significant occurrence of elevated proteinuria. The level of in-vitro IgG production by GVH spleen cells correlated closely with the degree of autoimmunity.
- Subjects
AUTOIMMUNITY; LABORATORY mice; IR genes; H-2 antigens; PROTEINURIA; IMMUNOGLOBULIN G
- Publication
Clinical & Experimental Immunology, 1986, Vol 65, Issue 3, p542
- ISSN
0009-9104
- Publication type
Article