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- Title
Effects of L-Glutamine on Various Gastric Lesions in Rats and Guinea Pigs.
- Authors
Okabe, S.; Takeuchi, K.; Takata, Y.; Naganuma, T.; Takagi, K.
- Abstract
Effects of L-glutamine on gastric lesion models in rats and guinea pigs were studied. Shay ulceration in rats was not inhibited by oral L-glutamine. Although stress-induced gastric lesions in intact rats were not inhibited by L-glutamine, a strong antagonism of gastric lesions was induced in pylorus-ligated rats under the same stress by the amino acid. Histamine-induced gastric lesions in intact rats and guinea pigs were also markedly inhibited by L-glutamine. L-Glutamine inhibited the gastric lesions in rats induced by compound 48/80 but not significantly. Reserpine- or serotonin-induced gastric lesions in rats were not affected by L-glutamine. The mechanism of L-glutamine protection was discussed. Copyright © 1976 S. Karger AG, Basel
- Publication
Digestion, 1976, Vol 14, Issue 4, p325
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000197948