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- Title
Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment.
- Authors
Sriboonnark, Leelawadee; Arora, Harleen; Falto-Aizpurua, Leyre; Choudhary, Sonal; Connelly, Elizabeth Alvarez
- Abstract
We report the case of 17-year-old female diagnosed with Costello syndrome. Genetic testing provided a proof with G12S mutation in the HRAS gene since 3 years of age with a presentation of severe nodulocystic acne on her face. After 2 months of oral isotretinoin treatment, improvement in her acne was observed. Interestingly, an unexpected significant improvement of acanthosis nigricans on her neck and dorsum of her hands was found as well. We present this case as a successful treatment option by using oral isotretinoin for the treatment of acanthosis nigricans in Costello syndrome patients.
- Subjects
COSTELLO syndrome; ACANTHOSIS nigricans; NODULAR disease; ISOTRETINOIN; GENETIC testing; GENETIC mutation; HRAS genes; DIAGNOSIS; THERAPEUTICS
- Publication
Case Reports in Pediatrics, 2015, Vol 2015, p1
- ISSN
2090-6803
- Publication type
Article
- DOI
10.1155/2015/934865