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- Title
Angiotensin II type 1 receptor antibodies and native kidney function in pediatric liver and intestinal transplant recipients.
- Authors
Stern, Rachel; Chen, Lucia; Chan, Alvin P.; Wozniak, Laura J.; Pearl, Meghan
- Abstract
Background: Angiotensin II type-1 receptor antibody (AT1R-Ab) has been associated with vascular injury and kidney dysfunction in pediatric kidney transplant recipients. The role of AT1R-Ab in the development of chronic kidney disease in pediatric liver and intestinal transplant recipients has not been explored. Methods: Twenty-five pediatric intestinal transplant recipients and 79 pediatric liver transplant recipients had AT1R-Ab levels measured at varying time points in the post-transplant period. Estimated glomerular filtration rate (eGFR) was determined using creatinine based CKiD U25 equation and measured at time of AT1R-Ab measurement, at 1 year post-AT1R-Ab measurement, at 5 years post-AT1R-Ab measurement, and at the most recent routine clinic visit. The prevalence of hypertension and antihypertensive medication use were also evaluated. Results: Younger age at time of AT1R-Ab measurement was associated with AT1R-Ab positivity in liver transplant recipients. There was no association between AT1R-Ab status and change in eGFR, prevalence of hypertension, or use of antihypertensive medications at the described time points. Conclusions: AT1R-Ab positivity was not associated with a decline in eGFR or hypertension in pediatric liver and intestinal transplant recipients. Further studies are needed using other markers of kidney function, such as cystatin C, to validate this finding.
- Subjects
CALIFORNIA; INTESTINE transplantation; CHRONIC kidney failure; GLOMERULAR filtration rate; HYPERTENSION; IMMUNOGLOBULINS; HLA-B27 antigen; GRAFT rejection; CELL receptors; PATIENTS; RETROSPECTIVE studies; RISK assessment; RESEARCH funding; DESCRIPTIVE statistics; LIVER transplantation; ANGIOTENSIN II; TRANSPLANTATION of organs, tissues, etc.; CREATININE; DISEASE risk factors; CHILDREN
- Publication
Pediatric Nephrology, 2023, Vol 38, Issue 12, p4175
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-023-06055-0