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- Title
Tissue‐resident memory T (T<sub>RM</sub>) cells: Front‐line workers of the immune system.
- Authors
Osman, Maleika; Park, Simone L.; Mackay, Laura K.
- Abstract
Tissue‐resident memory T (TRM) cells play a vital role in local immune protection against infection and cancer. The location of TRM cells within peripheral tissues at sites of pathogen invasion allows for the rapid detection and elimination of microbes, making their generation an attractive goal for the development of next‐generation vaccines. Here, we discuss differential requirements for CD8+ TRM cell development across tissues with implications for establishing local prophylactic immunity, emphasizing the role of tissue‐derived factors, local antigen, and adjuvants on TRM cell generation in the context of vaccination.
- Subjects
IMMUNE system; IMMUNOLOGIC memory; VACCINE development; PSYCHONEUROIMMUNOLOGY
- Publication
European Journal of Immunology, 2023, Vol 53, Issue 11, p1
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.202250060