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- Title
Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence.
- Authors
Lázničková, Petra; Kepák, Tomáš; Hortová – Kohoutková, Marcela; Horváth, Luděk; Sheardová, Kateřina; Marciniak, Rafal; Vacca, Carmine; Šiklová, Michaela; Zelante, Teresa; Rossmeislová, Lenka; Křenová, Zdenka; Štěrba, Jaroslav; Bendíčková, Kamila; Frič, Jan
- Abstract
Keywords: adverse late effects; childhood; immune recovery; immunosenescence; neuroblastoma EN adverse late effects childhood immune recovery immunosenescence neuroblastoma 2092 2094 3 12/14/20 20201201 NES 201201 Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8 SP + sp T cell compartment and elevated plasma TNF- but in later follow-up immune recovery comes into play. Immunosenescence is recognized by increased plasma IL-6, TNF- , and CRP [3] combined with expansion of CD8 SP + sp T cell subsets expressing CD57, a marker of proliferative senescence, and lacking CD28 and CD27 [4]. Taken together, nCCS at early time-points post-treatment show significant differences in their CD8 SP + sp T cell compartment compared to children who have not undergone cancer treatment, but by 5 or more years post-diagnosis the lymphocyte subsets of nCCS resemble those of healthy control children.
- Subjects
NEUROBLASTOMA; IMMUNOSENESCENCE; OLDER people; HEMATOPOIETIC stem cell transplantation
- Publication
European Journal of Immunology, 2020, Vol 50, Issue 12, p2092
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.202048541