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- Title
γδ T cells support gut Ag-reactive colitogenic effector T-cell generation by enhancing Ag presentation by CD11b<sup>+</sup> DCs in the mesenteric LN.
- Authors
Do, Jeongsu; Visperas, Anabelle; Freeman, Michael L.; Jang, Eunjung; Kim, Sohee; Malissen, Bernard; Min, Booki
- Abstract
T cells expressing the γδ TCR are dominant T-cell subsets in the intestinal immune system. We previously demonstrated that γδ T cells play important roles in augmenting Th17-type colitogenic immune responses in a T-cell-induced colitic inflammation model. However, its underlying mechanism remains poorly understood. In this study, an in vitro coculture system using effector T cells enriched in gut Ag-reactive cells was employed as a readout tool to search for gut Ag presenting APCs. We found that the presence of γδ T cells dramatically enhances gut Ag presentation within the mLN in mice. Gut Ag presentation by CD11b+ DC subsets was particularly controlled by γδ T cells. Interestingly, γδ T-cell entry to the lymph nodes was essential to improve the Ag presentation. Therefore, our results highlight that γδ T cells play a previously unrecognized role to support colitogenic immunity by regulating gut Ag presentation in the draining LN.
- Publication
European Journal of Immunology, 2016, Vol 46, Issue 2, p340
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201545919