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- Title
CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC.
- Authors
Maggi, Laura; Santarlasci, Veronica; Capone, Manuela; Peired, Anna; Frosali, Francesca; Crome, Sarah Q.; Querci, Valentina; Fambrini, Massimiliano; Liotta, Francesco; Levings, Megan K.; Maggi, Enrico; Cosmi, Lorenzo; Romagnani, Sergio; Annunziato, Francesco
- Abstract
We have previously shown that human Th17 lymphocytes are characterized by the selective expression of IL-23 receptor (IL-23R), CCR6, CD161, and the transcription factor retinoic acid-related orphan receptor C (RORC), and originate from a CD161CD4 naïve T-cell precursor in response to the combined activity of IL-1β and IL-23. We show here that not only CD4TCRαβ, but also CD8TCRαβ, CD4CD8 TCRαβ, and CD4CD8 TCRγδ circulating lymphocytes that produce IL-17 express the distinctive marker CD161 on their surface. In addition, we demonstrate that CD161 expression identifies CD8 and CD4CD8 umbilical cord blood T cells that already express RORC and IL-23R mRNA and that can be induced to differentiate into IL-17-producing cells in the presence of IL-1β and IL-23. Finally, we provide evidence that umbilical cord blood naïve CD4CD161 T cells, upon lentivirus-mediated transduction with RORC2 can acquire the ability to express IL-23R, IL-1RI, and CD161, as well as to produce IL-17. Taken together, these data allow to conclude that T-cell subsets able to produce IL-17, as well as precursors of IL-17-producing T cells, exhibit surface expression of CD161, and that this feature is at least in part RORC2-dependent.
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 8, p2174
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200940257