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- Title
MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models.
- Authors
Chuffa, Luiz Gustavo A.; Pinheiro, Patricia Fernanda F.; Eduardo Martinez, Francisco; Fioruci-Fontanelli, Beatriz Aparecida; Mendes, Leonardo O.; Delella, Flávia Karina; Felisbino, Sérgio Luis; Kurokawa, Cilmery S.
- Abstract
We investigated whether chronic ethanol intake is capable of altering the MMP-2 and MMP-9 activities and TIMP-2 and TIMP-1 expression in the dorsal and lateral prostatic lobes of low (UChA) and high (UChB) ethanol-preferring rats. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were significantly reduced in the lateral prostatic lobe of the ethanol drinking animals. Dorsal prostatic lobe was less affected showing no significant alterations in these proteins, except for a reduction in the TIMP-1 expression in UChA rats. These important findings demonstrate that chronic ethanol intake impairs the physiological balance of the prostate extracellular matrix turnover, through downregulation of MMPs, whichmay contribute to the development of prostatic diseases. Furthermore, since these proteins are also components of prostate secretion, the negative impact of chronic ethanol intake on fertility may also involve reduction of MMPs and TIMPs in the seminal fluid.
- Subjects
PROSTATE cancer; ALCOHOLISM; MATRIX metalloproteinases; PEPTIDASE; GLYCOPROTEINS
- Publication
Analytical Cellular Pathology: Cellular Oncology, 2015, Vol 2015, p1
- ISSN
2210-7177
- Publication type
Article
- DOI
10.1155/2015/954548