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- Title
Lymph node evaluation in stage IIA colorectal cancer and its impact on patient prognosis: A population-based study.
- Authors
Iachetta, Francesco; Reggiani Bonetti, Luca; Marcheselli, Luigi; Di Gregorio, Carmela; Cirilli, Claudia; Messinese, Simona; Cervo, Gian L.; Postiglione, Raffaella; Di Emidio, Katia; Pedroni, Monica; Longinotti, Ernesto; Federico, Massimo; Ponz de Leon, Maurizio
- Abstract
Background. The analysis of regional lymph nodes is particularly relevant in patients with stage II colorectal cancer, in whom the role of adjuvant chemotherapy remains unclear. The aim of this study was to assess the relationship between number of examined lymph nodes and survival in patients with stage IIA (pT3N0M0) colorectal cancer, and to determine the optimal number of lymph nodes that should be examined. Methods. The study group included all the surgically-treated colorectal cancer patients in stage IIA (n = 657) who were identified through the population-based Cancer Registry of the Province of Modena (Northern Italy), during the period 2002-2006. Results. The median number of harvested lymph nodes was 19 (range 1-68). Considering, as a reference point, patients with 12 or less lymph nodes, subjects with n ≥ 20 lymph nodes examined showed, in univariate analysis, a significantly higher cancer specific (p = 0.01) and relapse-free survival (p = 0.003). The results were confirmed by multivariate analysis (Cox model). Conclusion. The result suggests that colorectal cancer patients in stage IIA with n ≥ 20 lymph nodes examined exhibit better survival when compared with subjects in whom fewer lymph nodes were examined. The number of 20 lymph nodes is the essential requirement for an oncologic resection of the large bowel.
- Subjects
ITALY; RECTUM tumors; COLON tumors; CHI-squared test; COMBINED modality therapy; CONFIDENCE intervals; REPORTING of diseases; FISHER exact test; LYMPH nodes; STATISTICAL hypothesis testing; STATISTICS; SURVIVAL analysis (Biometry); PROPORTIONAL hazards models; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; PROGNOSIS
- Publication
Acta Oncologica, 2013, Vol 52, Issue 8, p1682
- ISSN
0284-186X
- Publication type
Article
- DOI
10.3109/0284186X.2013.808376