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- Title
Prostaglandin Synthase 2/Cyclooxygenase 2 Gene Polymorphisms and Susceptibility to Urothelial Bladder Cancer in an Iranian Population.
- Authors
Mansori, Kamyar; Nowroozi, Mohammad Reza; Farzin, Amirreza; Moghadam, Solmaz Ohadian
- Abstract
Background: Prostaglandin-endoperoxide synthase 2, recognized as cyclooxygenase 2 (COX-2), is an important enzyme contributing to the generation of proinflammatory prostaglandins. It can play a role in increased tumor angiogenesis, apoptosis inhibition, metastasis, and invasion of tumors. Single nucleotide polymorphisms (SNPs) of the COX-2 promoter may associate with the cancer predisposition. In the present work, we aimed to explore whether SNPs of COX-2 gene affect both the risk of development and grade of bladder cancer. Method: This case-control study was performed and the genetic polymorphisms of six COX-2 SNPs including, intron 1 (rs2745557), intron 5 (rs16825748), intron 6 (rs2066826), T+8473C (rs5275), G-765 (rs20417), and A-1195G (rs68946) were genotyped in 80 healthy controls and 80 bladder cancer patients using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). To select independent prognostic factors, the univariate and multivariate analyses were implemented. Results: Univariate logistic regression model indicated a significant association between COX-2 765G>C heterozygous GC genotype and greater risk of bladder cancer (OR: 2.07; 95% CI: 1.03 - 4.15; P = 0.04). However, the multivariate logistic regression analysis showed no associations between COX-2 variants and bladder cancer development. Conclusion: We concluded that COX-2 polymorphisms do not contribute to the genetic susceptibility to urothelial bladder cancer in an Iranian population. However, the only genotype in which the frequency of alleles significantly differed between the two groups of high-grade tumors and low-grade tumors was COX-2 8473T> C (rs5275). Moreover, our findings showed that both smoking and family history of cancer play a role in susceptibility to bladder cancer.
- Subjects
IRAN; BLADDER tumors; PROSTAGLANDINS; CYCLOOXYGENASE 2; EPITHELIAL cell tumors; STATISTICS; CONFIDENCE intervals; NONSTEROIDAL anti-inflammatory agents; SINGLE nucleotide polymorphisms; CANCER invasiveness; MULTIVARIATE analysis; MULTIPLE regression analysis; APOPTOSIS; CASE-control method; GENETIC polymorphisms; DISEASE susceptibility; GENOTYPES; DESCRIPTIVE statistics; LOGISTIC regression analysis; ODDS ratio; DATA analysis software
- Publication
Middle East Journal of Cancer, 2022, Vol 13, Issue 3, p418
- ISSN
2008-6709
- Publication type
Article
- DOI
10.30476/mejc.2021.88204.1463