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- Title
Efeito antiedematogênico da planta Vernonia scorpioides frente ao veneno de Bothrops fonsecai e carragenina.
- Authors
Monteiro Pereira, Danielle; Carlos Cogo, José; Regina Zamuner, Stella
- Abstract
Introduction: Pharmacological studies have shown that extracts of some plants used in traditional medicine have anti-inflammatory, anti-viral and anti-ophidic properties. Objective: To evaluate the anti-edematogenic effect of V. scorpioides against Bothrops fonsecai venom (VBF) and carrageenan. Methods: Wistar rats (n=24, 4 animals per group) were used. The hidroalcoolic extract of V. scorpioides (EHVs) was placed into bottle of the animals for five consecutive days. On the fifth day, the venom (0.25 mg / paw) or carrageenan (500 ?g/paw) was injected in the rats, according to the treatment group, and the edematogenic effect was evaluated by plethysmography at different times. Results: Oral administration of EHVs in rats significantly reduced the edematogenic effect at two and three hours after VBF administration and three until six hours after carrageenan injection. Conclusion: V. scorpioides can be an alternative, used orally, to control the inflammation that result in edema formation.
- Subjects
ANIMAL experimentation; MEDICINAL plants; SNAKE venom; RATS; PLANT extracts
- Publication
ConScientiae Saúde, 2012, Vol 11, Issue 1, p46
- ISSN
1677-1028
- Publication type
Article
- DOI
10.5585/ConsSaude.v11n1.2862