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- Title
CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy.
- Authors
Chen, Shuliang; Yu, Xiao; Guo, Deyin
- Abstract
Currently, a new gene editing tool--the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system--is becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, has been developed and applied to antiviral research in humans. Based on the characteristics of virus-host interactions and the basic rules of nucleic acid cleavage or gene activation of the CRISPR-Cas system, it can be used to target both the virus genome and host factors to clear viral reservoirs and prohibit virus infection or replication. Here, we summarize recent progress of the CRISPR-Cas technology in editing host genes as an antiviral strategy.
- Subjects
CRISPRS; GENOME editing; IMMUNE system; HOST-virus relationships; NUCLEIC acids
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 1, p40
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10010040