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- Title
Jaagsiekte Sheep Retrovirus Biology and Oncogenesis.
- Authors
Hofacre, Andrew; Hung Fan
- Abstract
Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a lung cancer in sheep known as ovine pulmonary adenocarcinoma (OPA). The disease has been identified around the world in several breeds of sheep and goats, and JSRV infection typically has a serious impact on affected flocks. In addition, studies on OPA are an excellent model for human lung carcinogenesis. A unique feature of JSRV is that its envelope (Env) protein functions as an oncogene. The JSRV Env-induced transformation or oncogenesis has been studied in a variety of cell systems and in animal models. Moreover, JSRV studies have provided insights into retroviral genomic RNA export/expression mechanisms. JSRV encodes a trans-acting factor (Rej) within the env gene necessary for the synthesis of Gag protein from unspliced viral RNA. This review summarizes research pertaining to JSRV-induced pathogenesis, Env transformation, and other aspects of JSRV biology.
- Subjects
RETROVIRUSES; RETROVIRUS diseases; LUNG cancer; ADENOCARCINOMA; CANCER in animals; CARCINOGENESIS; PREVENTION
- Publication
Viruses (1999-4915), 2010, Vol 2, Issue 12, p2618
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v2122618