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- Title
Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica.
- Authors
Mathew, Jessy Elizabeth; Keloth Kaitheri, Srinivasan; DinakaranVachala, Seekarajapuram; Jose, Magi
- Abstract
Objective(s) Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their antiinflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.
- Subjects
HERBAL medicine; ANTI-inflammatory agents; ANTIPRURITICS; MAST cells; ETHANOL; INDIAN birthwort; THERAPEUTICS
- Publication
Iranian Journal of Basic Medical Sciences, 2011, Vol 14, Issue 5, p422
- ISSN
2008-3866
- Publication type
Article