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- Title
Thermal Stability and Kinetic Study of Fluvoxamine Stability in Binary Samples with Lactose.
- Authors
Ghaderi, Faranak; Nemati, Mahboob; Siahi-Shadbad, Mohammad Reza; Valizadeh, Hadi; Monajjemzadeh, Farnaz
- Abstract
Purpose: In the present study the incompatibility of FLM (fluvoxamine) with lactose in solid state mixtures was investigated. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fouriertransform infrared (FTIR) spectroscopy and mass spectrometry. Methods: Non-Isothermally stressed physical mixtures were used to calculate the solid-state kinetic parameters. Different thermal models such as Friedman, Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) were used for the characterization of the drug-excipient interaction. Results: Overall, the incompatibility of FLM with lactose as a reducing carbohydrate was successfully evaluated and the activation energy of this interaction was calculated. Conclusion: In this research the lactose and FLM Maillard interaction was proved using physicochemical techniques including DSC and FTIR. It was shown that DSC-based kinetic analysis provides fast and versatile kinetic comparison of Arrhenius activation energies for different pharmaceutical samples.
- Subjects
FLUVOXAMINE; THERMAL stability; THERMAL properties; LACTOSE metabolism; LACTOSE in the body; THERAPEUTICS
- Publication
Advanced Pharmaceutical Bulletin, 2017, Vol 7, Issue 1, p43
- ISSN
2228-5881
- Publication type
Article
- DOI
10.15171/apb.2017.006