We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Systemic Signature of the Lung Response to Respiratory Syncytial Virus Infection.
- Authors
Pennings, Jeroen L. A.; Schuurhof, Annemieke; Hodemaekers, Hennie M.; Buisman, Annemarie; De Rond, Lia C. G. H.; Widjojoatmodjo, Myra N.; Luytjes, Willem; Kimpen, Jan L. L.; Bont, Louis; Janssen, Riny
- Abstract
Respiratory Syncytial Virus is a frequent cause of severe bronchiolitis in children. To improve our understanding of systemic host responses to RSV, we compared BALB/c mouse gene expression responses at day 1, 2, and 5 during primary RSV infection in lung, bronchial lymph nodes, and blood. We identified a set of 53 interferon-associated and innate immunity genes that give correlated responses in all three murine tissues. Additionally, we identified blood gene signatures that are indicative of acute infection, secondary immune response, and vaccine-enhanced disease, respectively. Eosinophilassociated ribonucleases were characteristic for the vaccine-enhanced disease blood signature. These results indicate that it may be possible to distinguish protective and unfavorable patient lung responses via blood diagnostics.
- Subjects
RESPIRATORY syncytial virus infections; LUNG diseases; BRONCHIOLES; GENE expression; LABORATORY mice; BLOOD testing; JUVENILE diseases; VIRAL vaccines
- Publication
PLoS ONE, 2011, Vol 6, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0021461