OpenURL Connection Search

Select item for more details and to access through your institution.

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036402
By:
- Wallin, Jeffrey J.;
- Guan, Jane;
- Edgar, Kyle A.;
- Wei Zhou;
- Francis, Ross;
- Torres, Anthony C.;
- Haverty, Peter M.;
- Eastham-Anderson, Jeffrey;
- Arena, Sabrina;
- Bardelli, Alberto;
- Griffin, Sue;
- Goodall, John E.;
- Grimshaw, Kyla M.;
- Hoeflich, Klaus P.;
- Torrance, Christopher;
- Belvin, Marcia;
- Friedman, Lori S.
Publication type:
Article
Combined Targeting of BRAF and CRAF or BRAF and PI3K Effector Pathways Is Required for Efficacy in NRAS Mutant Tumors.
Published in:
PLoS ONE, 2009, v. 4, n. 5, p. 1, doi. 10.1371/journal.pone.0005717
By:
- Jaiswal, Bijay S.;
- Janakiraman, Vasantharajan;
- Kljavin, Noelyn M.;
- Eastham-Anderson, Jeffrey;
- Cupp, James E.;
- Yuxin Liang;
- Davis, David P.;
- Klaus P. Hoeflich;
- Seshagiri, Somasekar
Publication type:
Article
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Published in:
Nature, 2010, v. 464, n. 7287, p. 431, doi. 10.1038/nature08833
By:
- Hatzivassiliou, Georgia;
- Song, Kyung;
- Yen, Ivana;
- Brandhuber, Barbara J.;
- Anderson, Daniel J.;
- Alvarado, Ryan;
- Ludlam, Mary J. C.;
- Stokoe, David;
- Gloor, Susan L.;
- Vigers, Guy;
- Morales, Tony;
- Aliagas, Ignacio;
- Liu, Bonnie;
- Sideris, Steve;
- Hoeflich, Klaus P.;
- Jaiswal, Bijay S.;
- Seshagiri, Somasekar;
- Koeppen, Hartmut;
- Belvin, Marcia;
- Friedman, Lori S.
Publication type:
Article
Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).
Published in:
Oncogene, 1999, v. 18, n. 42, p. 5814, doi. 10.1038/sj.onc.1202975
By:
- Hoeflich, Klaus P;
- Yeh, Wen-Chen;
- Yao, Zhengbin;
- Mak, Tak W;
- Woodgett, James R
Publication type:
Article
Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts.
Published in:
Oncogene, 1999, v. 18, n. 23, p. 3520, doi. 10.1038/sj.onc.1202716
By:
- Lee, Si Tuen;
- Hoeflich, Klaus P;
- Wasfy, Gihane W;
- Woodgett, James R;
- Leber, Brian;
- Andrews, David W;
- Hedley, David W;
- Penn, Linda Z
Publication type:
Article
Targeting cancer with kinase inhibitors.
Published in:
2015
By:
- Gross, Stefan;
- Rahal, Rami;
- Stransky, Nicolas;
- Lengauer, Christoph;
- Hoeflich, Klaus P
Publication type:
journal article
Requirement for glycogen synthase kinase-3beta in cell survival and NF-KB activation.
Published in:
Nature, 2000, v. 406, n. 6791, p. 86, doi. 10.1038/35017574
By:
- Hoeflich, Klaus P.;
- Luo, Juan;
- Rubie, Elizabeth A.;
- Ming-Sounc Tsao;
- Ou Jin;
- Woodgett, James R.
Publication type:
Article
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Published in:
Journal of Cell Biology, 2008, v. 183, n. 1, p. 101, doi. 10.1083/jcb.200801099
By:
- Degtyarev, Michael;
- De Mazière, Ann;
- Orr, Christine;
- Lin, Jie;
- Lee, Brian B.;
- Tien, Janet Y.;
- Prior, Wei W.;
- van Dijk, Suzanne;
- Hong Wu;
- Gray, Daniel C.;
- Davis, David P.;
- Stern, Howard M.;
- Murray, Lesley J.;
- Hoeflich, Klaus P.;
- Klumperman, Judith;
- Friedman, Lori S.;
- Kui Lin
Publication type:
Article
Erratum: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Published in:
Nature, 2013, v. 502, n. 7470, p. 258, doi. 10.1038/nature12659
By:
- Hatzivassiliou, Georgia;
- Haling, Jacob R.;
- Chen, Huifen;
- Song, Kyung;
- Price, Steve;
- Heald, Robert;
- Hewitt, Joanne F. M.;
- Zak, Mark;
- Peck, Ariana;
- Orr, Christine;
- Merchant, Mark;
- Hoeflich, Klaus P.;
- Chan, Jocelyn;
- Luoh, Shiuh-Ming;
- Anderson, Daniel J.;
- Ludlam, Mary J. C.;
- Wiesmann, Christian;
- Ultsch, Mark;
- Friedman, Lori S.;
- Malek, Shiva
Publication type:
Article
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Published in:
Nature, 2013, v. 501, n. 7466, p. 232, doi. 10.1038/nature12441
By:
- Hatzivassiliou, Georgia;
- Haling, Jacob R.;
- Chen, Huifen;
- Song, Kyung;
- Price, Steve;
- Heald, Robert;
- Hewitt, Joanne F. M.;
- Zak, Mark;
- Peck, Ariana;
- Orr, Christine;
- Merchant, Mark;
- Hoeflich, Klaus P.;
- Chan, Jocelyn;
- Luoh, Shiuh-Ming;
- Anderson, Daniel J.;
- Ludlam, Mary J. C.;
- Wiesmann, Christian;
- Ultsch, Mark;
- Friedman, Lori S.;
- Malek, Shiva
Publication type:
Article
pHUSH: a single vector system for conditional gene expression.
Published in:
BMC Biotechnology, 2007, v. 7, p. 1, doi. 10.1186/1472-6750-7-61
By:
- Gray, Daniel C;
- Hoeflich, Klaus P;
- Peng, Li;
- Gu, Zhenyu;
- Gogineni, Alvin;
- Murray, Lesley J;
- Eby, Mike;
- Kljavin, Noelyn;
- Seshagiri, Somasekar;
- Cole, Mary J;
- Davis, David P
Publication type:
Article
P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma.
Published in:
JNCI: Journal of the National Cancer Institute, 2013, v. 105, n. 9, p. 606, doi. 10.1093/jnci/djt054
By:
- Ong, Christy C.;
- Jubb, Adrian M.;
- Jakubiak, Diana;
- Zhou, Wei;
- Rudolph, Joachim;
- Haverty, Peter M.;
- Kowanetz, Marcin;
- Yan, Yibing;
- Tremayne, Jarrod;
- Lisle, Richard;
- Harris, Adrian L.;
- Friedman, Lori S.;
- Belvin, Marcia;
- Middleton, Mark R.;
- Blackwood, Elizabeth M.;
- Koeppen, Hartmut;
- Hoeflich, Klaus P.
Publication type:
Article

Found: 12