We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibitory Effect of Spirulina maxima on the Azoxymethane-induced Aberrant Colon Crypts and Oxidative Damage in Mice.
- Authors
Álvarez-González, Isela; Islas-Islas, Víctor; Chamorro-Cevallos, Germán; Pablo Barrios, Juan; Paniagua, Norma; Vásquez-Garzón, Verónica R.; Villa-Treviño, Saúl; Osiris-Madrigal-Santillán; Morales-González, José Antonio; Madrigal-Bujaidar, Eduardo
- Abstract
Background: Spirulina maxima (Sm) is a cyanobacterium well known because of its high nutritive value, as well as its anti-inflammatory, anti-hyperlipidemic, antioxidant, and anti-genotoxic activities. Objective: To determine the capacity of Sm to inhibit the induction of aberrant colon crypts (AC), as well as the level of lipid peroxidation and DNA oxidative damage in mice treated with azoxymethane (AOM). Materials and Methods: Sm (100, 400, and 800 mg/kg) was daily administered to animals by the oral route during 4 weeks, while AOM (10 mg/kg) was intraperitoneally injected to mice twice in weeks 2 and 3 of the assay. We also included a control group of mice orally administered with distilled water along the assay, as well as other group orally administered with the high dose of Sm. Results: A significant decrease in the number of AC with the three tested doses of Sm, with a mean protection of 51.6% respect to the damage induced by AOM. Also, with the three doses of the alga, we found a reduction in the level of lipoperoxidation, as well as in regard to the percentage of the DNA adduct 8-hydroxy-2'-deoxyguanosine. Conclusion: Sm possesses anti-precarcinogenic potential in vivo, as well as capacity to reduce the oxidative damage induced by AOM.
- Subjects
GENETIC regulation; CYANOBACTERIAL enzymes; GENE expression; PHYSIOLOGICAL effects of antioxidants; GENETIC toxicology; CYANOBACTERIA
- Publication
Pharmacognosy Magazine, 2015, Vol 11, pS619
- ISSN
0973-1296
- Publication type
Article
- DOI
10.4103/0973-1296.172973