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- Title
Association of Vascular Endothelial Growth Factor Polymorphisms with Asthma in Tunisian Children.
- Authors
Lachheb, Jihene; Chelbi, Hanene; Dhifallah, Imen Ben; Ammar, Jamel; Hamzaoui, Kamel; Hamzaoui, Agnès
- Abstract
Background: Previous studies demonstrated that the vascular endothelial growth factor (VEGF) was being implicated in the airways inflammation and remodeling process in patients with asthma. Aims: We explored the relationship of three polymorphisms in the VEGF gene with asthma in both case control and family studies. Methods: We Genotyped a total of 210 children with asthma, 224 unrelated controls and 160 parents for the +936 C > T (rs3025039), -634 G > C (rs2010963) and ?2549 -2567 del 18 of the VEGF promoter region. The Mutations were identied with polymerase chain reaction followed by restriction fragment length polymorphism (RFLP) analysis for the +936 C > T, and ?634 G > C polymorphisms. Results: Of the three polymorphisms studied, a borderline association with asthma was found for the G allele in the ?634 G > C polymorphism (p = 0.059). No Statistically significant differences were observed for both +936 C > T, and ?2549 -2567 del 18 polymorphisms between asthmatic patients and controls, considering either allelic or genotypic frequencies. The distribution of genotypes according to the severity status revealed a signicant differences for the +936 C > T, and -2549 -2567 del 18 polymorphisms. In addition, association was found with the haplotypes inferred by the three polymorphisms and asthma susceptibility. Conclusion: We suggest that VEGF Gene polymorphisms can be implicated in asthma.
- Subjects
TUNISIA; VASCULAR endothelial growth factors; GENETIC polymorphisms; ASTHMA in children; GENETIC mutation; POLYMERASE chain reaction
- Publication
Gene Regulation & Systems Biology, 2008, Issue 2, p89
- ISSN
1177-6250
- Publication type
Article
- DOI
10.1177/117762500800200003