We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enhancing the Cytotoxic Activity of Anticancer Pt<sup>IV</sup> Complexes by Introduction of Lonidamine as an Axial Ligand.
- Authors
Nosova, Yulia N.; Foteeva, Lidia S.; Zenin, Ilia V.; Fetisov, Timur I.; Kirsanov, Kirill I.; Yakubovskaya, Marianna G.; Antonenko, Taisya A.; Tafeenko, Viktor A.; Aslanov, Leonid A.; Lobas, Anna A.; Gorshkov, Mikhail V.; Galanski, Markus; Keppler, Bernhard K.; Timerbaev, Andrei R.; Milaeva, Elena R.; Nazarov, Alexey A.
- Abstract
The synthesis and in vitro cytotoxicity of a series of PtIV complexes with lonidamine as a ligand coordinated in axial position are described. Lonidamine was found to affect strongly the in vitro cytotoxic activity of these new complexes, lowering the IC50 values down to the nanomolar range. Lipophilicity assessed in terms of log P showed no direct correlation with cytotoxicity.
- Subjects
CELL-mediated cytotoxicity; LONIDAMINE; COMPLEX compounds; LIPOPHILICITY; STATISTICAL correlation
- Publication
European Journal of Inorganic Chemistry, 2017, Vol 2017, Issue 12, p1785
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201600857