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- Title
A Functional Connectome of Parkinson's Disease Patients Prior to Deep Brain Stimulation: A Tool for Disease-Specific Connectivity Analyses.
- Authors
Loh, Aaron; Boutet, Alexandre; Germann, Jürgen; Al-Fatly, Bassam; Elias, Gavin J. B.; Neudorfer, Clemens; Krotz, Jillian; Wong, Emily H. Y.; Parmar, Roohie; Gramer, Robert; Paff, Michelle; Horn, Andreas; Chen, J. Jean; Azevedo, Paula; Fasano, Alfonso; Munhoz, Renato P.; Hodaie, Mojgan; Kalia, Suneil K.; Kucharczyk, Walter; Lozano, Andres M.
- Abstract
Finally, we showed that despite the considerable disparities in size of the Tor-PD ( I n i = 75) and Healthy connectomes ( I n i = 1,000), when performing analyses with PD DBS patient data, functional connectivity of VTAs to certain motor ROIs computed with the Tor-PD connectome could significantly explain variance in clinical outcome, whereas connectivity computed with the Healthy connectome could not. Moreover, when we examined the effect of different MRI hardware, the number of significantly different voxels between raw I r- i maps from either connectome was the same when computed with the full Tor-PD connectome or a subset of the Tor-PD connectome using 3T rs-fMRI acquisitions (58 scans) only. Keywords: Parkinson's disease; functional connectivity; connectomics; neuromodulation; functional magnetic resonance imaging EN Parkinson's disease functional connectivity connectomics neuromodulation functional magnetic resonance imaging 1 9 9 06/28/22 20220624 NES 220624 Background and Summary A wide range of disorders are thought to arise from dysfunction in brain circuitry (Bonelli and Cummings, [4]).
- Subjects
DEEP brain stimulation; PARKINSON'S disease; MOVEMENT disorders; LARGE-scale brain networks; FUNCTIONAL magnetic resonance imaging
- Publication
Frontiers in Neuroscience, 2022, Vol 16, p1
- ISSN
1662-4548
- Publication type
Article
- DOI
10.3389/fnins.2022.804125