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- Title
A Mild and General One-Pot Synthesis of Densely Functionalized Diaryliodonium Salts.
- Authors
Qin, Linlin; Hu, Bao; Neumann, Kiel D.; Linstad, Ethan J.; McCauley, Katelyenn; Veness, Jordan; Kempinger, Jayson J.; DiMagno, Stephen G.
- Abstract
Diaryliodonium salts are powerful and widely used arylating agents in organic chemistry. Here we report a scalable synthesis of densely functionalized diaryliodonium salts from aryl iodides under mild conditions. This two-step, one-pot process has remarkable functional group tolerance, is compatible with commonly employed acid-labile protective group strategies, avoids heavy metal and transition metal reagents, and provides a direct route to stable precursors to PET imaging agents.
- Subjects
SALTS; IODINE compounds synthesis; ARYL iodides; OXIDATION; FUNCTIONAL groups; POSITRON emission tomography
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 27, p5919
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201500986