We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impacto de darbepoetina alfa en el manejo de la anemia precoz postrasplante renal: estudio retrospectivo exploratorio.
- Authors
Jiménez, Carlos; González, Esther; Marqués, María; Galeano, Cristina; Andrés, Amado; Calvo, Natividad; Pascual, Julio
- Abstract
Background and objectives: The use of darbepoetin alfa in the first week of post-renal transplant (RT). Methods: Retrospective observational study carried out in four hospitals, which included all adult patients that underwent RT for 9 months with haemoglobin data during the first 6 months of post-transplant (n = 129). Darbepoetina alfa was administered in accordance with the clinical practice. Results: darbepoetin alfa was administered in the first week to 60 individuals (46.5%), who had a mean baseline Hb (± standard deviation) of 12.7g/dl±1.6g/dl. Anaemia incidence (Hb < 11g/dl) during the first month was higher in patients who did not receive darbepoetin alfa (40.6% vs. 25.0% in patients treated with darbepoetin alfa, P=.045). No anaemia incidence differences were observed during months +2 to +6. There was a tendency towards transfusion decrease in patients who received darbepoetin alfa (13.3% vs. 20.3%, P=.295). Renal recovery time was similar but in the subgroup which received grafts from donors with asystole there was a tendency towards a faster recovery with darbepoetin alfa (15.1±7.7 vs. 20.1±8.8 days, P=.157). The creatinine clearance rate at 3 and 6 months was similar. Fourteen patients (10.9%) suffered from cardiovascular events with no relation to darbepoetin alfa (P=.772). Conclusions: Administering darbepoetin alfa in the first week following renal transplant reduces anaemia incidence during the first month without increase cardiovascular events.
- Subjects
ANEMIA; KIDNEY transplantation; HEMOGLOBINS; DARBEPOETIN alfa; BLOOD transfusion; MANAGEMENT
- Publication
Nefrologia, 2013, Vol 33, Issue 1, p107
- ISSN
0211-6995
- Publication type
Article
- DOI
10.3265/Nefrologia.pre2012.Oct.11473