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- Title
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery
- Authors
Movafegh, Ali; Eslamian, Laleh; Dorabadi, Azita
- Abstract
<bold>Objective: </bold>To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery.<bold>Methods: </bold>One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded.<bold>Results: </bold>The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001).<bold>Conclusion: </bold>Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.
- Subjects
CESAREAN section; CARBOCYCLIC acids; DRUG administration; BLOOD loss estimation; DELIVERY (Obstetrics); PLACEBOS; OXYTOCIN; HEMORRHAGE prevention; ANTIFIBRINOLYTIC agents; SURGICAL blood loss; TRANEXAMIC acid; COMPARATIVE studies; HEMORRHAGE; INTRAVENOUS therapy; RESEARCH methodology; MEDICAL cooperation; PUERPERAL disorders; RESEARCH; EVALUATION research; UTERINE hemorrhage; RANDOMIZED controlled trials; BLIND experiment; OXYTOCICS; PREVENTION; THERAPEUTICS
- Publication
International Journal of Gynecology & Obstetrics, 2011, Vol 115, Issue 3, p224
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2011.07.015