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- Title
Mapping the landscape of human dopamine D2/3 receptors with [<sup>11</sup>C]raclopride.
- Authors
Papenberg, Goran; Jonasson, Lars; Karalija, Nina; Johansson, Jarkko; Köhncke, Ylva; Salami, Alireza; Andersson, Micael; Axelsson, Jan; Wåhlin, Anders; Riklund, Katrine; Lindenberger, Ulman; Lövdén, Martin; Nyberg, Lars; Bäckman, Lars
- Abstract
The dopamine D2/3 system is fundamental for sensory, motor, emotional, and cognitive aspects of behavior. Small-scale human histopathological and animal studies show high density of D2/3 dopamine receptors (D2/3DR) in striatum, but also demonstrate the existence of such receptors across cortical and limbic regions. Assessment of D2/3DR BPND in the extrastriatal regions with [11C]raclopride has long been considered unreliable due to the relatively low density of D2/3DR outside the striatum. We describe the distribution and interregional links of D2/3DR availability measured with PET and [11C]raclopride across the human brain in a large sample (N = 176; age range 64–68 years). Structural equation modeling revealed that D2/3DR availability can be organized according to anatomical (nigrostriatal, mesolimbic, mesocortical) and functional (limbic, associative, sensorimotor) dopamine pathways. D2/3DR availability in corticolimbic functional subdivisions showed differential associations to corresponding striatal subdivisions, extending animal and pharmacological work. Our findings provide evidence on the dimensionality and organization of [11C]raclopride D2/3DR availability in the living human brain that conforms to known dopaminergic pathways.
- Subjects
DOPAMINE receptors; STRUCTURAL equation modeling; PET therapy
- Publication
Brain Structure & Function, 2019, Vol 224, Issue 8, p2871
- ISSN
1863-2653
- Publication type
Article
- DOI
10.1007/s00429-019-01938-1