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- Title
Synthesis, characterization, and anticancer properties of iminophosphineplatinum(II) complexes containing boronate esters.
- Authors
St-Coeur, Patrick-Denis; Kinley, Samantha; Vogels, Christopher M.; Decken, Andreas; Jr. Morin, Pier; Westcott, Stephen A.
- Abstract
Three new iminophosphines containing pinacol-derived boronate esters have been prepared and ligated to dichloridoplatinum(II) fragments. All compounds have been characterized fully, including an X-ray diffraction study carried out for the platinum complex 8, which is derived from 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. These three new platinum complexes, along with the non-boron containing control, have been examined for their initial cytotoxic properties against two glioma cell lines using the MTT method.
- Subjects
IMINO compounds; PLATINUM; ANTINEOPLASTIC agents; BORON; BORONIC esters; GLIOMAS
- Publication
Canadian Journal of Chemistry, 2017, Vol 95, Issue 2, p207
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2016-0570