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- Title
A direct method for the synthesis of indolizine derivatives from easily available aromatic ketones, pyridines, and acrylonitrile derivatives.
- Authors
Cai, Qun; Zhu, Yan-Ping; Gao, Yang; Sun, Jing-Jing; Wu, An-Xin
- Abstract
A concise and efficient strategy has been proposed to synthesize indolizine derivatives from easily available aryl or heteroaryl methyl ketones, pyridines, and acrylonitriles. The mechanistic pathway involved the integration of iodination, pyridinium ylide synthesis, and 1,3-dipolar cycloaddition. The protocols were found to be highly efficient in terms of high yields, operational simplicity, mild reaction conditions, and easy workup. This method has provided an important supplement for the synthesis of indolizine derivatives via a novel tandem synthesis.
- Subjects
KETONES; AROMATIC compounds; PYRIDINE; ACRYLONITRILE; IODINATION
- Publication
Canadian Journal of Chemistry, 2013, Vol 91, Issue 6, p414
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2012-0534