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- Title
A Primary Immune Response to Dextran B512 is Followed by a Period of Antigen-specific Immunosuppression Caused by Autoanti-idiotypic Antibodies.
- Authors
Fernandez, C.; Möller, G.
- Abstract
After a primary immune response to the alpha 1-6 epitope of dexiran B512, dextran high responder strains exhibit a specific inability to produce IgM und IgG antibodies against this epitope, although they gave unexpected secondary response to horse erythrncytes. Spleen cells from dextran-primed and-suppressed mice responded well to dextran after transfer to lethally irradiated previously untreated mice, indicating that tolerance or exhaustive proliferation of dextran reactive B cells is not responsible. Thymus-dependent dextran protein conjugates also induced specific suppression. Suppression to both dextran and horse erythrocytes could be passively transferred into untreated recipients with immune scrum. However, after absorption with horse erythrocyles and dextran, passive serum transfer only suppressed the response lo dexiran. It is suggested that the specific immunosuppression was caused by the appearance of autoanti-idiotypic antibodies directed against the immunoglobulin receptors of dextran-reactive B cells.
- Subjects
IMMUNOREGULATION; IMMUNOGLOBULIN G; LYMPHOCYTES; ENDOCRINE glands; BLOOD plasma; GLUCOSE; LABORATORY rats
- Publication
Scandinavian Journal of Immunology, 1980, Vol 11, Issue 1, p53
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1980.tb00208.x