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- Title
Independent Segregation of Two Functional Markers Expressed on the Same B-Cell Subset in the Mouse: The Mls Determinants and LPS Receptors.
- Authors
Coutinho, A.; Meo, T.; Watanabe, T.
- Abstract
Mice of the C3H/Tif strain display a mixed leukocyte reaction (MLR) with all H-2k strains carrying any of the known alleles of the Mls locus. In particular. C3H/Tif is incompatible with the related substrain C3H/HeJ, front which it also differs at the locus responsible for the recognition of Iipopolysaccharides (LPS) as B-cell mitogens and at the Mod-1 locus. Our generic analysis indicates that the MLR incompatibility between these strains is not H-2-linked and segregates as controlled by a single locus, most probably identical to Mls, for which the C3H/Tif strain expresses a previously unidentified allele, Mls.... Moreover, segregation data show that this locus assorts independently of LPS responsiveness and that neither marker is closely linked to the Mod-1 locus in linkage group II.
- Subjects
B cells; LYMPHOCYTES; LEUCOCYTES; MITOGENS; ENDOTOXINS; MICROBIAL polysaccharides
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 10, p1007
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00336.x