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- Title
Demonstration of Human T Lymphotropic Virus Type I (HTLV-I)-Specific T Cell Responses from Seronegative and Polymerase Chain Reaction-Negative Persons Exposed to HTLV-I.
- Authors
Nishimura, Masataka; Kermode, Allan G; Clerici, Mario; Shearer, Gene M.; Berzofsky, Jay A.; Uchiyama, T.; Wiktor, Stefan Z.; Pate, Ernest; Maloney, Beth; Manns, Angela; Blattner, William; Jacobson, Steven
- Abstract
Human T lymphotropic virus type I (HTLV-I) is a human retrovirus etiologically linked to adult TcellleukemiaandtheprogressivechronicneurologicdiseaseHTLV-I-associatedmyelopathy/tropical spastic paraparesis. Described is a method that measures the production of interleukin-2 from HTLV-I synthetic peptide-stimulated peripheral blood lymphocytes (PBL) of HTLV-I-infected persons. The peptides correspond to immunogenic regions of the HTLV-I Env and Tax proteins. Significantly, this assay demonstrated T cell responses to these HTLV-I peptides from coded PBL samples in 7 of 19 HTLV-I-seronegative polymerase chain reaction-negative persons known to have been exposed to HTL V-I but in none of 16 matched controls without risk factors for exposure (P = .007). The implications of this finding are discussed.
- Publication
Journal of Infectious Diseases, 1994, Vol 170, Issue 2, p334
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/170.2.334